What is NovoSeven® RT (Coagulation Factor VIIa [Recombinant])?
NovoSeven® RT is the only recombinant
factor VII (7)
Factor VII (7)
One of the 13 clotting-factor proteins that helps form blood clots. product available for the treatment of bleeding Bleeding
In hemophilia, a collection of blood in an area, such as a muscle or joint. episodes and prevention of surgical bleeding in patients with hemophilia A Hemophilia A
A bleeding disorder caused by lack of Factor VIII (8). It is sometimes called classic or standard hemophilia. or B Hemophilia B
A bleeding disorder caused by lack of Factor IX (9). with inhibitors Inhibitor
A substance made by the body that attacks factor so it cannot work as well. For example, a Factor VIII (8) inhibitor would keep Factor VIII from working with other factors and platelets to stop bleeding. to factor VIII (8) Factor VIII (8)
One of the 13 clotting-factor proteins that helps form blood clots. or factor IX (9) Factor IX (9)
One of the 13 clotting-factor proteins that helps form blood clots. , patients with acquired hemophilia Acquired hemophilia
A form of hemophilia in which the body starts producing antibodies that fight its own blood-clotting proteins. , patients with congenital factor VII deficiency, and patients with Glanzmann's thrombasthenia who have a decreased or absent response to platelet transfusions.
How NovoSeven® RT works
There are a number of factors
A protein in the blood that helps form blood clots. in the clotting Clotting
The process of forming into a clot or clots. process. Clotting happens when each factor works together in the right order. The clotting process can be slowed or stopped if 1 factor is blocked or missing. In order for a stable clot Clot
The thickened mass of blood and cells your body forms to stop the bleeding at the place where you have been injured. to form, the deficient Deficient
A lack or shortage of something. factor in the blood-clotting Blood clotting
Also known as coagulation. It is the process of turning some of the elements in the blood into a clot. Blood clotting is the result of a sequence of actions and reactions that involve several different proteins in the blood. process must be replaced or bypassed.
NovoSeven® RT is called a bypassing agent
A product that treats a bleed without the need for Factor VIII (8) or Factor IX (9). because it skips the need for factor VIII or IX in people with inhibitors, instead activating factor X (10) directly. For people with factor VII deficiency Factor VII (7) deficiency
A rare bleeding disorder in which the blood has low levels of Factor VII. Factor VII is important in the blood-clotting process because it binds to blood cells near the location of an injury and to activated platelets, setting the clotting process in motion., NovoSeven® RT is used to replace the missing factor, so the clotting process can continue.