NovoSeven® RT (Coagulation Factor VIIa [Recombinant]) is effective at controlling bleeds in people with Glanzmann’s thrombasthenia (GT)
who have a decreased or absent response to platelet transfusions
What is GT?
There are proteins on the platelets that help your blood clot properly. One of these proteins is called glycoprotein. One glycoprotein called 2B-3A helps platelets connect to each other by binding to fibrinogen strands, forming bridges between platelets. Those platelets stick together to form a “plug” that stops a bleed.
Someone with GT has specific defective glycoprotein. This means the platelets cannot form a plug to stop a bleed.
Who gets GT?
GT is a rare genetic disorder that affects about 1 in 1 million people. It is inherited from both parents and can occur in both men and women.
Signs of GT
Those with GT mainly have skin and mucous membrane types of bleeding. The most common signs of GT include:
- Easy bruising
- Bleeding from the nose or gums
- Heavy menstruation (in women)
Other signs and symptoms include:
- Excessive bleeding after trauma or surgery
- Excessive bleeding after dental extractions
- Red- or black-colored stools
- Vomit that is black and syrupy or bright red
- Blood in the urine
- Painful swelling or warmth around a joint may rarely occur
GT is a serious condition and bleeding can be unpredictable. A healthcare provider should always be consulted before treatment begins.