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NovoSeven® RT (Coagulation Factor VIIa [Recombinant]) does not raise inhibitor titers*

A titer Titer
Concentration or strength of a substance; measures the strength of an inhibitor in a person’s blood.
measures the strength of an inhibitor Inhibitor
A substance made by the body that attacks factor so it cannot work as well. For example, a Factor VIII (8) inhibitor would keep Factor VIII from working with other factors and platelets to stop bleeding.
. The higher the titer in the blood, the stronger the inhibitor. With NovoSeven® RT, you do not have to worry about raising your titer.

BU=Bethesda unit.
  • NovoSeven® RT was associated with decreases in inhibitor titers when used as the only factor Factor
    A protein in the blood that helps form blood clots.
    treatment in a study

People with inhibitors want to keep their titers low. However, factor VIII (8) Factor VIII (8)
One of the 13 clotting-factor proteins that helps form blood clots.
and factor IX (9) Factor IX (9)
One of the 13 clotting-factor proteins that helps form blood clots.
can raise titers.

No risk of increased titers with NovoSeven® RT
  • NovoSeven® RT is the only bypassing agent Bypassing agent
    A product that treats a bleed without the need for factor VIII (8) or Factor IX (9).
    that does not contain any factor VIII or IX, so there is no risk of increased titers with treatment

*Inhibitors to factor VIII or IX.


Indications and Usage

NovoSeven® RT (Coagulation Factor VIIa [Recombinant]) is used for:

Important Safety Information


  • Serious blood clots that form in veins and arteries with the use of NovoSeven® RT have been reported.
  • Your healthcare provider should discuss the risks and explain the signs and symptoms of blood clots to you. Some signs of a blood clot may include pain, swelling, warmth, redness, or a lump in your legs or arms, chest pain, shortness of breath, or sudden severe headache and/or loss of consciousness or function.
  • Your healthcare provider should monitor you for blood clots during treatment with NovoSeven® RT.

Warnings and Precautions

Side Effects

Use with Other Drugs

Please click here for NovoSeven® RT Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit,
or call 1-800-FDA-1088.

NovoSeven® RT is a prescription medicine. Novo Nordisk provides patient assistance for those who qualify. Please call 1-877-NOVO-777 (1-877-668-6777) to learn more about Novo Nordisk assistance programs.