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NovoSeven® RT does not raise inhibitor titers*
A titer
Titer
Concentration or strength of a substance; measures the strength of an inhibitor in a person’s blood.
measures the strength of an inhibitor
Inhibitor
A substance made by the body that attacks factor so it cannot work as well. For example, a Factor VIII (8) inhibitor would keep Factor VIII from working with other factors and platelets to stop bleeding.
. The higher the titer in the blood, the stronger the inhibitor. With NovoSeven® RT, you do not have to worry about raising your titer.
Adapted from Brackmann et al, Eur J Haematol, 1998.a
aData from a study of patients with hemophilia A and high-responding inhibitors. Ten patients were given rFVIIa for treatment of bleeds; 6 of these 10 patients were also undergoing immune tolerance induction (ITI). Figure lines reflect decrease in inhibitor titers after switch to NovoSeven® RT in the 4 patients not undergoing ITI.
- NovoSeven® RT is associated with decreases in inhibitor titers when used as the only factor
Factor
A protein in the blood that helps form blood clots.treatment
People with inhibitors want to keep their titers low. However, Factor VIII (8)
Factor VIII (8)
One of the 13 clotting-factor proteins that helps form blood clots.
and Factor IX (9)
Factor IX (9)
One of the 13 clotting-factor proteins that helps form blood clots.
can raise titers.
No risk of increased titers with NovoSeven® RT
- NovoSeven® RT is the only bypassing agent
Bypassing agent
A product that treats a bleed without the need for Factor VIII (8) or Factor IX (9).that does not contain any Factor VIII or IX, so there is no risk of increased titers with treatment
*Inhibitors to Factor VIII or IX.
