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An effective therapy option for you.

NovoSeven® RT is the only recombinant treatment indicated for Glanzmann's thrombasthenia (GT) when platelets don't work.

How it helps

Controls bleeds, wherever and whenever they happen.

Rely on NovoSeven® RT—it is proven effective to treat GT at home. Clinical trials show it controls bleeds in a majority of GT-related bleeds, and in surgical procedures.

Bleed control seen in clinical trialsa

94 percent effective

Bleeding episodes
266 episodes
All treatmentsb

99 percent effective

Surgical procedures
160 procedures
All treatmentsb

Effectiveness in childrena

  • 94% bleed control in patients 0 to 12 years
  • 100% bleed control in patients >12 to 16 years


aEffectiveness seen in a prospective, observational, multinational study (from an analysis of published cases and people who took part in trials and registries).
b
NovoSeven® RT only and NovoSeven® RT with platelets and/or antifibrinolytics.

Safety

Safety supported by clinical experience.

NovoSeven® RT is a recombinant product, meaning it is made without human blood or plasma. This minimizes the possibility of viral contamination. NovoSeven® RT is the only recombinant therapy indicated for GT.c And its safety is supported by real-world evidence, with a <0.2% rate of unexpected blood clots reported.d

Serious blood clots that form in veins and arteries with the use of NovoSeven® RT have been reported.

cIn patients with refractoriness to platelet transfusions, with or without antibodies to platelets.
dThrombotic events reported for people with GT based on registry data collected.

Icon: Microscrope
Fast infusions

Fast to infuse.

NovoSeven® RT provides low infusion volume, so infusing takes 2 to 5 minutes.e NovoSeven® RT is given as an intravenous (IV) bolus injection.  

eAdminister as a slow bolus injection over 2 to 5 minutes, depending on the dose administered.

NovoSeven® RT (90 mcg/kg)

2-5 minutes

Meet Cathy.

She chooses NovoSeven® RT because it fits her lifestyle.

Travel and mixing

Goes where you go.

NovoSeven® RT is portable and travel ready, with compact packaging that’s easy to pack in a carry-on or backpack. And because it’s room temperature stable up to 77°F, there’s no need to refrigerate.f  

fNovoSeven® RT should be stored between 36°F and 77°F.

For complete storage information, please see Prescribing Information.

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Quick to mix.g

NovoSeven® RT with MixPro® makes mixing a dose as easy as attach, twist, and mix. The prefilled syringe saves time—there are no extra steps to fill a syringe with diluent.

MixPro instructions

After mixing, NovoSeven® RT may be stored at room temperature in the vial for up to 3 hours.h  

gCompared with mixing using histidine vials.
hFor complete storage and handling instructions, please see Prescribing Information.

Surgery

What if I need surgery or a procedure?

We understand that you have concerns about controlling bleeds if you ever need surgery or a procedure. The good news is that NovoSeven® RT prevents bleeds during and after surgery and procedures in people with GT.

Talk to your doctor for more information on the surgical use of NovoSeven® RT.

FAQs

About Glanzmann’s thrombasthenia (GT).

Question

What is GT?

Answer

There are proteins on the platelets that help your blood clot properly. One type of these proteins is a glycoprotein called IIb/IIIa, which helps platelets connect to each other. Those platelets stick together to form a "plug" that stops a bleed. Someone with GT has specific defective glycoprotein IIb/IIIa. This means the platelets cannot form a plug to stop a bleed.
 

Question

Who gets GT?

Answer

GT is a rare genetic disorder that affects about 1 in 1 million people. It is inherited from both parents and can occur in both men and women.
 

Question

What are the signs of GT?

Answer

Those with GT mainly have skin and mucous membrane types of bleeding. The most common signs of GT include:

  • Easy bruising
  • Bleeding from the nose or gums
  • Heavy menstruation

Other signs and symptoms include:

  • Excessive bleeding after trauma or surgery
  • Excessive bleeding after dental extractions
     
Question

What are some treatments for GT?

Answer

One treatment option for GT is platelet transfusion; some patients who receive platelet transfusions may develop antibodies and become resistant. You may be able to use a bypassing agent to control your bleeds if platelets do not work for you.

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Justin and Chase

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Icon: 5-step purification process of NovoSeven® RT (Coagulation Factor VIIa [Recombinant])

Recombinant manufacturing

minimizes risk of viral contamination.

Selected Important Safety Information

What is the most important information I should know about NovoSeven® RT?

NovoSeven® RT may cause serious side effects, including:

  • Serious blood clots that form in veins and arteries with the use of NovoSeven® RT have been reported
  • Your healthcare provider should discuss the risks and explain the signs and symptoms of blood clots to you. Some signs of a blood clot may include pain, swelling, warmth, redness, or a lump in your legs or arms, chest pain, shortness of breath, or sudden severe headache and/or loss of consciousness or function
  • Your healthcare provider should monitor you for blood clots during treatment with NovoSeven® RT

What is NovoSeven® RT?

NovoSeven® RT (coagulation Factor VIIa, recombinant) is an injectable medicine used for:

  • Treatment of bleeding and prevention of bleeding for surgeries and procedures in adults and children with hemophilia A or B with inhibitors, congenital Factor VII (FVII) deficiency, and Glanzmann’s thrombasthenia with a decreased or absent response to platelet transfusions
  • Treatment of bleeding and prevention of bleeding for surgeries and procedures in adults with acquired hemophilia

Important Safety Information

What is the most important information I should know about NovoSeven® RT?

NovoSeven® RT may cause serious side effects, including:

  • Serious blood clots that form in veins and arteries with the use of NovoSeven® RT have been reported
  • Your healthcare provider should discuss the risks and explain the signs and symptoms of blood clots to you. Some signs of a blood clot may include pain, swelling, warmth, redness, or a lump in your legs or arms, chest pain, shortness of breath, or sudden severe headache and/or loss of consciousness or function
  • Your healthcare provider should monitor you for blood clots during treatment with NovoSeven® RT
  • You should not use NovoSeven® RT if you have ever had allergic (hypersensitivity) reactions, including severe, whole body reactions (anaphylaxis) to NovoSeven® RT, any of its ingredients, or mice, hamsters, or cows. Signs of allergic reaction include shortness of breath, rash, itching (pruritus), redness of the skin (erythema), or fainting/dizziness

What should I tell my healthcare provider before using NovoSeven® RT?

  • Tell your healthcare provider if you have any of the following, as these may increase your risk of blood clots:
    • congenital hemophilia and are also receiving treatment with aPCCs (activated prothrombin complex concentrates)
    • are an older patient particularly with acquired hemophilia and receiving other agents to stop bleeding
    • history of heart or blood vessel diseases
  • Tell your healthcare provider and pharmacist about all the medicines you take, including all prescription and non-prescription medicines, such as over-the-counter medicines, supplements, or herbal remedies

What are the possible side effects of NovoSeven® RT?

  • The most common and serious side effects are blood clots
  • Tell your healthcare provider about any side effects that bother you or do not go away, and seek medical help right away if you have signs of a blood clot or allergic reaction

Please click here for Prescribing Information